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50 ml
The first hexapeptide that is a mimic of the N-terminal end of SNAP-25 which competes with this protein for a position in the SNARE complex. Argireline® is an alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.
Transparent solution containing 0.05% active ingredient.
Water (Aqua), Acetyl Hexapeptide-8.
A unique antio-wrinkle peptide that has been shown in significant testing to be effective against the development of skin wrinkling, being a topical aleternative toBotulinum Toxin A.
Argireline® can be incorporated in cosmetics formulations where removal of the deep lines or wrinkles in the
forehead or around the eye area is desired.
One of the most striking signs of skin agiing is in creased wrinkling of the face. This can occur naturally over time and is identified by certain biochemical, histological and physiological changes that are amplified by environmental exposure and other secondary factors as the pull of gravity or repeated facial movements caused by the contraction of the muscles of facial expression.Muscles are contracted when they receive neurotransmitter release from inside a vesicle.
Argireline® mimics the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficeintly and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.
Water soluble.
In Vitro Action Mechanism
The neurotransmitter involved in muscle contraction is acetylcholine and it is released from a vesicle into the synapse. The SNARE protein complex is formed by three proteins: VAMP, Syntaxin, and SNAP-25 and it is essential for neurotransmitter release at the synapsis and mediates the final steps of exocytosis. This complex is like a cellular hook that captures vesicles and brings them close to the membrane to enable their fusion.
Botulinum Toxin A paralyses the mucle by selectively blocking acetylcholine release at the neuromuscular junction. BoNT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. The nerve signal cannot be relayed, the muscle cannot contract and it is paralysed.
Argireline® is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabalizes its formation, without breaking any of its components. If the SNARE complex is slightly destabalized, the vesicle cannot release neurotransmitters. As a consequence, muscle contraction is attenuated and the muscle is relaxed.
In Vitro Action Mechanism
Inhibition of glutamate release by depolarized vneuron cells is a validated cell assay for measuring the potential activity of compounds on the inhibition of neuronal exocytosis. Untreated neuron cultures were used as a negative control and cultures treated with Botulinum Toxin A (BoNT-A) were used as a positive control.
In Vivo Efficacy
This study was carried out in 10 healthy women volunteers. An O/W emulsion containing 10% Argireline® solution was applied twice daily around the eyes for 30 days. Silicon imprints were obtained pre-test and after 15 and 30 days. Analysis of the imprints were performed by confocal v laser scanning microscopy.

A cream containing 5% Argireline® solution was applied twice daily around the eyes of 14 volunteers, aged 39 to 64 for 28 days. Silicon imprints of the treated areas were measured by confocal profilometry.
Argireline shows a high inhibitory potential of glutamate release
The inhibition of glutamate release at mM concentration is a clear indicator of the potent anti-expression wrinkle activity of this hexapetide.
Reduction in the depth
of wrinkles up to 17%
after 15 days with 10%
Serutox Solution
The depth of the furrow
decreased a maximum
value of 32% in 28 days
* Argireline ® is a registered Trademark of
Lipotec Group Barcelona, Spain.
All images and content used with
permission from Lipotec

Greg, 45 - Omaha, NE

"I discovered Serutox almost by accident. Over 7 years ago, while still in my late thirties, I started to notice "crows feet" and wrinkles under my eyes due to sun exposure and heredity. I did like most people and tried nearly all of the over the counter brands with no success. I then saw an ad about a new wrinkle product that was originally designed to relieve stretch marks. I went on the internet to originally research that product but instead discovered another product named Serutox. There was an in depth analysis of the best anti wrinkle products and Serutox topped the list in every category. I tried it and have never looked back. Serutox really works and is by far a better value than Botox.

Cynthia Katsingris, 42 - Westfield, NJ

I started using Serutox in August of 2007. I remember this because I was on vacation in Greece and was talking to a pharmacist who recommended your product. She said it was natural and that it would help with the lines I was developing between my eyebrows from squinting in the brutal sun. When I got home I was thrilled to find out your product was made in the USA. Well, here we are 5 years later and all I have to say as a faithful user is, your product works. There still are no noticeable lines, it got rid of them and keeps them at bay, I have never done botox and with your product feel no need to. It even helps soften the expression lines on my forehead to the point where I don't even notice them. Thank you for a wonderful product that is easy to use and helps me age gracefully!

Siham Ganni - Montreal, Quebec

I have spent a lot of money on different products but the results were minimal or no results were shown at all until I heard about serutox . After I started using serutox , I actually realized that with serutox , the results were amazing and I was very happy about them. I recommend this product to anyone trying to get rid of wrinkles and is in need of something smooth to the skin.

Vanessa B. 53 - Cleveland, OH

"I started using Serutox 6 years ago for the lines on my forehead. After a couple of weeks of following the twice a day routine I was pleasantly surprised when I noticed the lines were disappearing! I was SO relieved the Serutox was working! I was getting so self-conscious I was contemplating Botox but was a little apprehensive to follow through. Thanks to the Serutox I won't even consider it!! Thank you for an amazing product!"